Cell signaling underlying epileptic behavior

Author: yneh

August undefined, 2024

WebAbstract. Epilepsy, a disorder of recurrent seizures, is a common and frequently devastating neurological condition. Available therapy is only symptomatic and often ineffective. Understanding epileptogenesis, the process by which a normal brain becomes epileptic, may help identify molecular targets for drugs that could prevent epilepsy. WebA seizure (from the Latin sacire—to take possession of) is the clinical manifestation of an abnormal, excessive, hypersynchronous discharge of a population of cortical neurons. Epilepsy is a disorder of the central …

Cell signaling underlying epileptic behavior - CORE

WebJul 18, 2024 · Tau is a microtubule-associated protein known to bind and promote assembly of microtubules in neurons under physiological conditions. However, under pathological conditions, aggregation of hyperphosphorylated tau causes neuronal toxicity, neurodegeneration, and resulting tauopathies like Alzheimer’s disease (AD). Clinically, … WebJan 26, 2024 · Autism spectrum disorders and epilepsies are heterogeneous human disorders that have miscellaneous etiologies and pathophysiology. There is considerable risk of frequent epilepsy in autism that facilitates amplified morbidity and mortality. Several biological pathways appear to be involved in disease progression, including gene … blackwater falls state park west virginia

Frontiers The role of dopamine signaling in epileptogenesis

WebEpilepsy is a complex disease, characterized by the repeated occurrence of bursts of electrical activity (seizures) in specific brain areas. The behavioral... DOAJ is a unique … WebJul 31, 2011 · Here we review the intracellular signaling pathways involved in the generation of seizures in epileptogenic areas. Pathways activated by modulatory … WebAug 26, 2024 · "Only 1 to 2% of neurons carrying mutations in the mTOR signaling pathway that regulates cell signaling in the brain have been found to include seizures in animal models of focal cortical ... fox news house of representatives

A mechanism underlying the most common cause of epileptic …

Cell signaling underlying epileptic behavior – DOAJ

WebSep 1, 2024 · Cell signaling underlying epileptic behavior. Front. Behav. Neurosci. (2011) J. Burtscher et al. The opioid system in temporal lobe epilepsy: functional role and therapeutic potential ... This study analyzed the cell surface expression of CCCs during epileptogenesis and during chronic epilepsy to evaluate if a loss of CCCs from the … WebSep 1, 2024 · Cell signaling underlying epileptic behavior. Front Behav Neurosci 2011; 5: 45. Crossref. PubMed. Google Scholar. 17. McDonald TS, Borges K. Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase. blackwater falls weather forecastWebSep 1, 2024 · Cell signaling underlying epileptic behavior. Front. Behav. Neurosci. (2011) J. Burtscher et al. The opioid system in temporal lobe epilepsy: functional role … blackwater falls state park winter

"WebMay 15, 2012 · Bozzi Y, Dunleavy M, Henshall DC (2011) Cell signaling underlying epileptic behavior. Front Behav Neurosci 5: 45. View Article Google Scholar 21. Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, … " - Cell signaling underlying epileptic behavior

Cell signaling underlying epileptic behavior

Webdescribe some of the major signaling pathways involved in short- and long-term cellular responses to seizure activity that are thought to underlie acute and chronic behaviors … WebThe majority of studies of signaling underlying epileptogenesis have centered on models that use focal seizures as the inciting agent for epileptogenesis; these include all of the …

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WebOct 7, 2024 · Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly understood due to the high complexity of affected neuronal circuits. To identify dysfunctional neuronal subtypes underlying seizure activity in the human brain, we have performed single-nucleus transcriptomi … WebDec 21, 2024 · Abstract. Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing ...

WebApr 7, 2024 · Bupleurum chinense DC. is a traditional Chinese medicine with a long medicinal history and is often used as the main ingredient in prescription drugs for epilepsy. The aerial parts of B. chinense DC. have similar efficacy and composition to B. chinense DC. Therefore, we speculated that the aerial parts of B. chinense DC. could be used in … WebNov 29, 2012 · Cell signaling underlying epileptic behavior. Front Behav Neurosci. 2011; 5:45. [PMC free article] [Google Scholar] Bozzi Y, Vallone D, Borrelli E. Neuroprotective role of dopamine against hippocampal cell death. J Neurosci. 2000; 20:8643–8649. [PMC free article] [Google Scholar] Busceti CL, Biagioni F, Aronica E, et al. Induction of the Wnt ...

WebFeb 24, 2015 · The bulk of the mutations associated with epilepsy are not in inhibitory or excitatory ion channels, so the mechanisms by which mutations lead to seizures and … National Center for Biotechnology Information

WebDec 1, 2024 · Dysregulation of a number of signaling pathways and genes has been associated with epileptic seizures (Bozzi et al., 2011). Among these cellular functions is autophagy ( Giorgi et al., 2015 ). The first evidence pointing to the role of autophagy in epilepsy has come from the observed effect of the autophagy enhancer rapamycin in …

WebClinical and experimental studies implicate most neuromodulatory systems in epileptogenesis. The dopaminergic system has a seizure-modulating effect that crucially depends on the different subtypes of dopamine (DA) receptors involved and the brain regions in which they are activated. Specifically, DA plays a major role in the control of … fox news house of representatives mapWebdescribe some of the major signaling pathways involved in short- and long-term cellular responses to seizure activity that are thought to underlie acute and chronic behaviors in the epileptic brain. fox news house map 2022WebApr 5, 2024 · Pilocarpine epileptic rat models have long-term seizures and show extensive cell loss, which resembles what has been discovered in patients with temporal lobe epilepsy. 9-12 ANT-DBS reduced the seizure rate and retarded the development of seizures in pilocarpine rats. 13-15 However, the underlying mechanisms remain unclear. fox news house of representatives countWebNov 29, 2012 · Bozzi Y, Dunleavy M, Henshall DC (2011) Cell signaling underlying epileptic behavior. Front Behav Neurosci 5:45. Article PubMed CAS Google Scholar Bozzi Y, Vallone D, Borrelli E (2000) Neuroprotective role of dopamine against hippocampal cell death. J Neurosci 20:8643–8649 fox news house of representatives resultsWebAug 26, 2024 · An interdisciplinary team studying neurogenetics, neural networks, and neurophysiology has revealed how dysfunctions in even a small percentage of cells can … fox news house projections fox news house of representatives 2022WebSep 1, 2024 · As previously demonstrated, the fraction Tb II-I causes epileptic-like behavior, electrographic alterations such as grouped spikes and strong discharges, ... Cell signaling underlying epileptic behavior. Front. Cell. Neurosci., 5 (2011), p. 45, 10.3389/fnbeh.2011.00045. Google Scholar. fox news house prediction