Chromomycin-a3

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August undefined, 2024

WebChromomycin A3 is an antibiotic that binds to the GC-rich sequence of DNA in the presence of divalent cations, inhibiting DNA replication and transcription (1). It is also used as a … http://www.cyto.purdue.edu/cdroms/cyto10a/sponsors/media/dako/mofloxdp/chromosome.pdf

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Chromomycin A3 (CMA3) or Toyomycin is an anthraquinone antibiotic glycoside produced by the fermentation of a certain strain of Streptomyces griseus (No. 7). See more In the presence of Mg ions, Chromomycin A3 binds reversibly to DNA, preferentially to contiguous G/C base pairs. When bound to DNA, Chromomycin A3 has a maximum excitation wavelength of 445 See more • in-vitro membrane-impermeant G/C-specific fluorescent DNA-binding dye. • in-vitro antibiotic of gram-positive bacteria, through inhibition of the incorporation of Pi in the RNA. • in-vitro anticancer drug that inhibits RNA synthesis. See more WebChromomycin A3 450 570 B, BV G-C Range 4, 6-Diamidino-2-Phenylindole HCl (DAPI) 372 456 U A-T Range Ethidium Bromide 545 605 G, IG DNA•RNA Hoechst 33258 365 465 U A-T Range Hoechst 33342 355 465 U A-T Range Mithramycin 395 570 BV G-C Range Olivomycin 430 ... duplicate these displays windows 11

Differential Interactions of the Mg2+ Complexes of Chromomycin A3 …

WebChromomycin A3. 230752-10MG. 80055-168EA 310.68 USD. 80055-168. Chromomycin A3. Chromomycin A3. Antibiotic that inhibits RNA synthesis. Excitation maximum: … WebChromomycin A 3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. 1, 2 Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species ... WebChromomycin A 3 is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used … duplicate the two content layout

Biosynthesis of the antitumor chromomycin A3 in …

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Web#: ALX-380-055 Chromomycin A 3 is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used with Bisbenzimide H33258 to distinguish chromosomes by their total DNA concentration and their DNA base composition. Does not intercalate. duplicate this displayWebG-C specific intercalating agents [actinomycin D (AMD) and chromomycin A3 at 1 microM] also prevented ER disappearance; ethidium bromide (EB) and quinacrine were ineffective. AMD and CHX operated immediately after their addition to the medium indicating an inhibitory action on the synthesis of an RNA and/or a peptide with high turnover rate ... duplicate this space

"WebJan 29, 2024 · CMA3 is an anthraquinone glycosidic antibiotic, produced by Streptomyces griseus ( 21 ). The anti-cancer effects of CMA3 have been proposed since the 1960s ( 22, 23 ). Side effects of CMA3 in advanced breast cancers have interrupted that use ( 24) but it is widely used for DNA staining ( 25 ). " - Chromomycin-a3

Chromomycin-a3

WebChromomycin A 3 and mithramycin are antibiotics binding preferentially to the GC-rich regions of DNA. They have excitation maxima at 440 nm and emission maxima at 555 … WebJun 2, 2024 · protamine deficiency by chromomycin A3 (CMA3) staining. In addition, the relationship between the fertilisation rate and sperm ubiquitination was calculated in ICSI candidates. The intensity of ubiquitination showed a significant negative correlation with sperm concentration (r = 0.255, P = 0.032) and a

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WebChromomycin A3 from Streptomyces griseus C57H82O26 CID 15953908 - structure, chemical names, physical and chemical properties, classification, patents, literature ... WebThis article is cited by 34 publications. Sangita Majee,, Ranjan Sen,, Suranjana Guha,, Dhananjay Bhattacharyya, and, Dipak Dasgupta. Differential Interactions of the Mg2+ Complexes of Chromomycin A3 and Mithramycin with Poly(dG-dC)·Poly(dC-dG) and Poly(dG)·Poly(dC).

WebNov 19, 1985 · The binding of chromomycin A3 to calf thymus DNA and poly (dG-dC) has been studied by 13C and 1H NMR with emphasis on the mode of binding, the role of Mg2+, and pH effects. WebChromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of …

WebChromomycin A3 as a fluorescent probe for flow cytometry of human gynecologic samples Author R H Jensen PMID: 70448 DOI: 10.1177/25.7.70448 Abstract Chemical, physical and optical properties of chromomycin A3 are examined so as to ascertain appropriate staining and analysis procedures for flow cytometry of human gynecologic samples. WebChromomycin A3 (CMA3) Protamination state of the spermatozoa determines its chromatin integrity status. The lesser the protamine content, the poorer the DNA packaging and the higher the sperm DNA damage. CMA3 binds to the sperm DNA deficient of protamine and stains light yellow [74]. The intensity of color is high in sperm with increased prot ...

Web其显示的人类染色体带型与Q带或G带相反，异染色质区如染色体的，一般在Q带或G显带中深染，常染色质区浅染，而R带则异染色质区一般浅染，常染色质区深染。. 其他R显带的方法包括用chromomycin A3或olivomycin等荧光素染色，或在细胞周期的合成期（S期）将 ...

WebJan 14, 2024 · Description. Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm … duplicate these displays not workingWebJun 7, 2024 · The Chromomycin A3 (CMA3) and Acridine orange (AO) staining were performed to examine the sperm DNA fragmentation status. CCl4 treatment showed a significant decrease in antioxidant markers and sperm count, viability, normal morphology and motility as well as significantly increased the testicular oxidative stress markers, and … duplicate ticketWebThe Township of Fawn Creek is located in Montgomery County, Kansas, United States. The place is catalogued as Civil by the U.S. Board on Geographic Names and its elevation … duplicate thumbWebChromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor. For research use only. We do not sell to patients. Chromomycin A3 … cryptids 2022WebBiosynthesis of mithramycin, chromomycin A3, and their derivatives has been investigated in detail . In addition to their antiproliferative potency, AA antibiotics demonstrate an antiviral activity [9,10]. Mithramycin has been tested as a neuroprotector for Huntington’s disease and neuronal death [11,12]. duplicate this picture into perfect conditionWebApplication: Chromomycin A3 is a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye CAS Number: 7059-24-7 Purity: ≥97% Molecular Weight: 1183.25 Molecular Formula: C 57 H 82 … cryptids across americaWebChromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. [ 3] It serves as a fluorescent DNA stain. [ 4] It is useful … cryptids and monsters youtube