WebJul 15, 2024 · Hepatotoxicity represents a relatively common and potentially serious side effect of anticancer therapies. Hepatotoxicity can manifest in many different ways … WebJun 26, 2024 · Neurotoxicity from high-dose cytarabine, a pyrimidine metabolite used in treatment for acute myeloid leukemia, is a known but dose-limiting toxicity which has incidences in up to 14% in patients receiving high doses of the drug. Neurologic symptoms vary but range from somnolence and ataxia to more severe complications such as …
(PDF) Acute Hepatotoxicity After High-Dose Cytarabine
WebCancer Type: Hematologic, Leukemia - Acute Lymphoblastic (ALL) Intent: Curative Regimen Category: evidence-informed Drugs Used: DOXOrubicin, vinCRIStine, dexamethasone, mercaptopurine, pegaspargase, Show More Funding: ODB - General Benefit ODB - General Benefit New Drug Funding Program Table of Contents DANAFARBERINT … WebCytarabine: Supportive Care Checklist PRN salt and soda oral mouth rinse PRN antiemetics Blood or platelet transfusions Acetaminophen every 6 hours as needed for fever 5-HT3 PLUS dexamethasone or NK1RA Prednisolone 1% 2 drops in each eye every 4-6 hours beginning before the first dose of cytarabine and continuing until 48 hours after … git push everything up to date error
Acute Hepatotoxicity After High-Dose Cytarabine for the …
WebGastrointestinal toxicity, anorexia, nausea, vomiting and diarrhea have been reported to occur but are mild to moderate in severity and rarely require hospitalization. • Rarely … WebCytarabine (1b-arabinofuranosylcytosine, cytosine arabinoside or ara-C) ... In another dog with grade III hepatotoxicity, ultrasonography and liver aspirates revealed neither vacuolar hepatopathy nor lymphoma, so this was attributed to cytarabine toxicity. Grade I and II elevations were seen in two further dogs but no further investigations ... WebThe DILIrank dataset consists of 1,036 FDA-approved drugs that are divided into four classes according to their potential for causing drug-induced liver injury (DILI). The DILI classification is... git push everything up to date