Rrm2 molecular weight

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August undefined, 2024

WebMolecular Weight (Da) 389. 44878. Protein Name. Ribonucleoside-diphosphate reductase subunit M2. Sources. UniProt. PhosphoSitePlus ®. GeneCards. WebRRM2. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 389. Protein existence. Evidence at protein level. Annotation score. 5/5. Entry. ... Molecular Function: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source:UniProtKB.

Recombinant Human RRM2 His Protein - Novus Biologicals

WebSep 13, 2016 · RRM2 is rate-limiting for the conversion of NTPs into dNTPs during the S-phase of the cell cycle ( 11 ). RRM2 is highly upregulated in melanoma cells harboring mutant BRAF V600E, and high RRM2 expression correlates with worse overall survival of patients with melanoma ( 12 ). WebRuthenium(II) Iodide molecular weight. Molar mass of RuI2 = 354.87894 g/mol. Convert grams Ruthenium(II) Iodide to moles. or. moles Ruthenium(II) Iodide to grams. Molecular … honda bintang cimone tangerang

RRM2 Antibody (NBP1-31661): Novus Biologicals

WebDec 28, 2024 · RNR consists of two subunits: the large subunit ribonucleotide reductase M1 (RRM1) and the small subunit (RRM2 or RRM2B). Interestingly, RRM2 is generally highly expressed in cancers [ 15 ]. It has been demonstrated that the overexpression of RRM2 is associated with drug and chemotherapy resistance [ 16, 17 ]. WebMar 28, 2024 · PDF Background: Ribonucleotide reductase regulatory subunit M2 (RRM2) has been reported to be an oncogene in some malignant tumors, such as lung... Find, read and cite all the research you ... WebJan 5, 2024 · This study was performed by investigating RRM2 protein expression in breast cancer and correlating the results with other clinicopathological variables using … honda bintang madiun

siRNA Knockdown of RRM2 Effectively Suppressed …

RRM2 Mediates the Anti-Tumor Effect of the Natural Product ...

WebMolecular Targeting of RRM2, NF-κB, and Mutant TP53 for the Treatment of Triple-Negative Breast Cancer Doxorubicin and other anthracycline derivatives are frequently used as part … WebFeb 28, 2009 · The human RRM2 gene specific siRNA (sc-36338) and scramble siRNA were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA). 5 × 10 5 /well KB cells were cultured in six-well plates with 2-mL antibiotic-free growth medium at 37°C in a CO 2 incubator for 24 hours. siRNA duplex-Lipofectamine was prepared by 6.0 μL of 10 μmol/L … fazendense zerozeroWebOct 23, 2024 · The analysis revealed that SC35 attaches to certain parts of a large, flexible protein called SRRM2. Ilik et al. discovered that although the structure and sequence of … honda biz usada ibitinga

"Web2 days ago · According to the previous literature, among the eight PFRs, five in the molecule set A don't all inhibit ferroptosis. RRM2 and AURKA may inhibit ferroptosis, but SLC2A1, SLC7A5 and PHKG2 are doubtful [[12], [13], [14]].According to the three conditions of “up-regulation in tumor tissue”, “worse OS”, and “inhibit ferroptosis”, two PFRs named RRM2 … " - Rrm2 molecular weight

Rrm2 molecular weight

SRRM2 Gene - GeneCards SRRM2 Protein SRRM2 Antibody

WebMay 1, 2024 · RRM2 knockdown promoted the degradation of CDK1 protein through autolysosome-dependent pathway by increasing autophagic flow, thereby inhibiting the proliferation of glioblastoma by inducing G2/M... WebCALAA-01 is a four-component, polymer-based nanoparticle siRNA delivery system. The siRNA was designed to reduce the expression of RRM2 (ribonucleotide reductase regulatory subunit M2), a key enzyme in nucleic acid metabolism. RRM2 is upregulated in many cancer types, and its suppression is proposed to result in cell cycle arrest and cell death ...

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WebMar 15, 2024 · Highly expressed RRM2 is associated with poor OS and DMFS of breast cancer patients. Furthermore, the high expression of RRM2 was associated with poor OS in breast cancer patients characterized by specific molecular subtypes (Luminal A subtype and Normal-like subtype) and specific stages (stage 1 and stage 2). WebJul 7, 2024 · The RRM2 mRNA levels were significantly upregulated by 2.2–5.6-fold in cancerous vs. normal tissues, while the mRNA levels of RRM1 and RRM2B were changed …

WebThe encoded protein has a calculated molecular weight of 47 kDa and contains four phosphorylation sites (serine at 366 and threonine at residues 302, 362, and 389) located at the C-terminal [2]. WebThis gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. …

WebAug 12, 2024 · RRM2 Background Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. It is composed of 2 non-identical subunits, … WebMar 21, 2024 · Size: 2752 amino acids Molecular mass: 299615 Da Protein existence level: PE1 Quaternary structure: Component of pre-catalytic, catalytic and post-catalytic spliceosome complexes (PubMed:11991638, 28502770, 28076346, 29361316, 29360106, 29301961, 30705154). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, …

WebJul 7, 2024 · The RRM2 mRNA levels were significantly upregulated by 2.2–5.6-fold in cancerous vs. normal tissues, while the mRNA levels of RRM1 and RRM2B were changed less in these studies (Fig. 1A ).

WebRRM2 is one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the … fazenda zenon vaca maruWebTargeted protein degradation (TPD) holds immense promise for drug discovery, but mechanisms of acquired resistance to degraders remain to be fully identified. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)-suppressor scanning to identify mechanistic classes of drug resistance mutations to molecular glue degraders in … honda bike wing malaysiaWebRBM10 is located in the nucleus; however, proteins with molecular weights less than 60 kDa can enter and exit the nucleus freely, while high molecular weight proteins such as RBM10 must pass through the NLS to enter and exit the nucleus. fazendi.haWebJul 27, 2024 · RRM2 is highly overexpressed in EwS, correlates with poor patient outcome, and constitutes a putative therapeutic target. a Schematic description of the filtering … honda bintaroWebDec 28, 2024 · The coding region of RRM2 comprises 1,170 nucleotides, which codes a protein of 389 amino acids with a calculated molecular mass of 44,883 Da. 11 The amino … honda biz guarapariWebMar 14, 2014 · For RRM2 and RRM2c, each GdnHCl titration sample was excited at 274 nm, and tyrosine emission spectra were collected from 280 to 400 nm at 20 or 37 °C with 5-nm slit widths. honda bismarck north dakotaWebRRM2 mRNA levels are normalized to TATA box-binding protein (TBP) mRNA levels. Results are presented as the percentage of the predosing RRM2 / TBP mRNA levels for each … honda blade 125 tahun 2012