WebFeb 1, 2024 · SMARCA4 is overexpressed, and SMARCA2 is underexpressed, in multiple types of tumors. First we compared the levels of SMARCA4 and SMARCA2 transcripts in … WebApr 11, 2024 · Title: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor Presenter: Koichi Ito Session Category: Experimental and Molecular Therapeutics Session Title: Epigenetics Date and Time: Wednesday April 19, 2024 9:00 AM – 12:30 PM Location: Section 20 Poster Board …
Prelude Therapeutics to Present at American Association for …
WebFeb 1, 2024 · SMARCA4 is the ATP-dependent catalytic unit of the complex. SMARCA4, as one of the most important mutually exclusive catalytic ATPase subunits, provides energy … WebFeb 24, 2024 · of SMARCA4 and SMARCA2 based on protein degradation could provide promising therapeutic opportunities (WO2016138114; Genentech and Constellation). … cissoid atlas
Simcere Zaiming will Present 8 Research Abstracts at the 2024 …
WebFeb 25, 2014 · This screen identified BRM/SMARCA2, a DNA-dependent ATPase of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex, as being essential for … WebApr 11, 2024 · Title: Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4- deficient solid tumor Presenter: Koichi Ito Session Category: Experimental and Molecular Therapeutics Session Title: Epigenetics Date and Time: Wednesday April 19, 2024 9:00 AM - 12:30 PM Location: Section 20 Poster Board … WebACBI2, shows selective degradation of the chromatin remodeler SMARCA2 over SMARCA4 in ex vivo human whole blood assays and in vivo efficacy in SMARCA4-deficient cancer … cissna wife